Four simple ingredients
What's in it?
iCalm is the first product that acts on 8 key cellular pathways involved in anxiety. Our ingredients were carefully picked and studied to find the most synergistic combination and ratios of all natural ingredients. We are also sure to use doses well above what has been shown to be clinically effective to ensure anyone that consumes the product will have noticeable relief.
Pillars of iCalm effectiveness:
Reduce hyperactive neurons
Decrease stress hormones
Stop inflammation in its tracks
Improve mood and focus
If you’re like us, a true health nut that really likes understanding HOW different supplements work in your body, then keep reading below for a deeper dive into the scientific explanations as to what anxiety is at the molecular level and how iCalm can extinguish even the most severe anxieties and keep them at bay for extended periods of time.
The science behind how iCalm works.
Our mood is dictated by various neurotransmitter systems. Different areas of your brain communicate through electrical messages that are conducted through neuron cell bodies. The tiny gap between the end of one neuron and beginning of another is a space called a synapse. It is here where neurotransmitters, the tiny chemical messengers that transmit signals between neurons, are released from the first neuron and bind receptors on the following neuron. There are many kinds of neurotransmitters, each having both distinct and overlapping functions with other types of neurotransmitters.
Everyone has heard of serotonin and dopamine, which are responsible for long-term senses of well-being and short-term pleasure, respectively. There’s also norepinephrine and noradrenaline, which are excitatory neurotransmitters. Whether you’re overwhelmed, anxious, or living through a full-blown panic attack, these two are dramatically elevated, thus leading to the classical symptoms of anxiety. We sought to create an all-natural drink that you can down in one gulp to instantly shift your brain chemistry away from stress and anxiety and towards an uplifting, focused, zenful state.
While balancing excitatory and inhibitory signaling is critical for anxiety, inflammation has also been linked to anxiety6. Luckily, Taurine has even been demonstrated to quell inflammation through a conversion into Taurine chloramine in response to inflammation7. This metabolite stops the production of interleukin-6 and -8, which are pro-inflammatory cytokines produced by white blood cells to promote inflammation8. This inflammation-anxiety link works both ways, as high stress has also been shown to initiate inflammation9. In today’s world of processed foods and pollutants, minimizing inflammation can not only be an uphill battle, but also a critical component in reducing stress. Given the wide array of calming mechanisms exerted by Taurine, it comes as no surprise that Taurine deficiencies are very common in not only anxiety, but epilepsy, and depression as well. Whether its intranasal administration of Taurine to mice10 or long term taurine supplementation in aging humans11, Taurine has been definitively proven to enhance not only GABA, but overall inhibitory signaling to reduce overexcitation.
Lemon Balm Extract
Our extensive testing results.
Through extensive testing, we have developed a proprietary blend of these ingredients to balance several converging anti-anxiety cellular mechanisms, including:
- GABAA receptor activation
- Promoting GABA synthesis
- Inhibition GABA breakdown
- Glycine receptor activation
- NMDA receptor inhibition
- Inhibiting Cortisol production
- Reducing pro-inflammatory cytokine production
- Antioxidant production
So rather than flooding your brain with excessive signaling for one signaling pathway (which could lead to drowsiness or other side effects), iCalm spreads out its therapeutic actions across numerous pathways and implicated in anxiety; resulting in rapid relief of both the mental and physical effects of anxiety, while also ensuring its therapeutic effect to persist for extended periods of time. It’s worth mentioning that our goal here was to leave you calm and cool as a cucumber, and NOT drowsy or sleepy. Thus, we made it a point to not use any overly sedating ingredients such as melatonin.
1. Nuss, P.J.N.d. & treatment. Anxiety disorders and GABA neurotransmission: a disturbance of modulation. 11, 165 (2015).
2. Jan, D.D.S., David‐Watine, B., Korn, H. & Bregestovski, P.J.T.J.o.P. Activation of human α1 and α2 homomeric glycine receptors by taurine and GABA. 535, 741-755 (2001).
3. Mori, M., Gähwiler, B.H. & Gerber,U.J.T.J.o.p. β‐Alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro. 539, 191-200 (2002).
4. El Idrissi, A. & L'Amoreaux, W.J.N. Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: in vivo functional test for the activity of glutamic acid decarboxylase. 156, 693-699 (2008).
5. Chan, C.Y. et al. Direct interaction of taurine with the NMDA glutamate receptor subtype via multiple mechanisms. in Taurine 8 45-52 (Springer, 2013).
6. Liu, Y.-Z., Wang, Y.-X. & Jiang, C.-L.J.F.i.h.n. Inflammation: the common pathway of stress-related diseases. 11, 316 (2017).
7. Kim, C. & Cha, Y.-N.J.A.A. Taurine chloramine produced from taurine under inflammation provides anti-inflammatory and cytoprotective effects. 46, 89-100 (2014).
8. Kontny, E. et al. The mechanism of taurine chloramine inhibition of cytokine (interleukin‐6, interleukin‐8) production by rheumatoid arthritis fibroblast‐like synoviocytes. 43, 2169-2177 (2000).
9. Salim, S., Chugh, G., Asghar, M.J.A.i.p.c. & biology, s. Inflammation in anxiety. 88, 1-25 (2012).
10. Jung, J.H., Kim, S.-J.J.B. & therapeutics. Anxiolytic action of taurine via intranasal administration in mice. 27, 450 (2019).
11. El Idrissi, A. et al. Functional implication of taurine in aging. in Taurine 7 199-206 (Springer, 2009).
12. White, D.J. et al. Anti-stress, behavioural and magnetoencephalography effects of an l-theanine-based nutrient drink: A randomised, double-blind, placebo-controlled, crossover trial. 8, 53 (2016).
13. Vreeburg, S.A. et al. Salivary cortisol levels in persons with and without different anxiety disorders. 72, 340-347 (2010).
14. Lenze, E.J. et al. Elevated cortisol in older adults with generalized anxiety disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram. 19, 482-490 (2011).
15. Kim, S., Jo, K., Hong, K.-B., Han, S.H. & Suh, H.J.J.P.b. GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. 57, 64-72 (2019).
16. Barkus, C., Dawson, L., Sharp, T., Bannerman, D.J.G., Brain & Behavior. GluN1 hypomorph mice exhibit wide‐ranging behavioral alterations. 11, 342-351 (2012).
17. Nobre, A.C., Rao, A. & Owen, G.N.J.A.P.j.o.c.n. L-theanine, a natural constituent in tea, and its effect on mental state. 17(2008).
18. Awad, R. et al. Bioassay‐guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. 23, 1075-1081 (2009).
19. Cases, J. et al. trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. 4, 211-218 (2011).
20. Scholey, A. et al.Anti-stress effects of lemon balm-containing foods. 6, 4805-4821 (2014).
21. Obulesu, M. & Rao, D.M.J.J.o.n.i.r.p.Effect of plant extracts on Alzheimer’s disease: An insight into therapeutic avenues. 2, 056-061 (2011).
22. Ribeiro, M., Bernardo-Gil, M. & Esquıvel, M.J.T.J.o.S.F. Melissa officinalis, L.: study of antioxidant activity in supercritical residues. 21, 51-60 (2001).
23. Zeraatpishe, A. et al. Effects of Melissa officinalis L. on oxidative status and DNA damage in subjects exposed to long-term low-dose ionizing radiation. 27, 205-212 (2011).